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Bayesian latent variable models for spatially correlated tooth-level binary data in caries research

机译:龋齿研究中与空间相关的牙齿水平二进制数据的贝叶斯潜变量模型

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摘要

Analysis of dental caries is traditionally based on aggregated scores, which are summaries of caries experience for each individual. A well-known example of such scores is the decayed, missing and filled teeth or tooth surfaces index introduced in the 1930s. Although these scores have improved our understanding of the pattern of dental caries, there are still some fundamental questions that remain unanswered. As an example, it is well believed among dentists that there are spatial symmetries in the mouth with respect to caries, but this has never been evaluated in a statistical sense. An answer to this question requires the analysis to be performed at subunits within the mouth, which necessitates the use of methods for correlated data. We propose a Bayesian generalized latent variable model coupled with an undirected graphical model to investigate the unique spatial distribution of tooth-level caries outcomes in the mouth. Data from the Signal Tandmobiel (R) study in Flanders, a dental longitudinal survey, are used to illustrate the methodology.
机译:龋齿的分析传统上是基于总得分的,总得分是每个人的龋齿经验总结。这种分数的一个众所周知的例子是1930年代引入的蛀牙,缺失牙齿和实心牙齿或牙齿表面指数。尽管这些分数提高了我们对龋齿模式的理解,但仍有一些基本问题尚待解答。例如,在牙医中,人们普遍认为口腔中相对于龋齿存在空间对称性,但从未在统计学意义上进行过评估。要回答这个问题,就需要在口中的亚基上进行分析,这需要使用相关数据的方法。我们提出贝叶斯广义潜变量模型与无向图形模型相结合,以研究口腔中龋齿结果的独特空间分布。来自弗兰德斯(Flanders)的Signal Tandmobiel(R)研究的数据(牙科纵向调查)用于说明该方法。

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